| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PON1 (20-150) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PON1 |
| Gene ID: |
5444 |
| Uniprot ID: |
PON1_HUMAN |
| Immunogen Region: |
20-150 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-150 of human PON1 (NP_000437.3). |
| Immunogen Sequence: |
HQSSYQTRLNALREVQPVEL PNCNLVKGIETGSEDLEILP NGLAFISSGLKYPGIKSFNP NSPGKILLMDLNEEDPTVLE LGITGSKFDVSSFNPHGIST FTDEDNAMYLLVVNHPDAKS TVELFKFQEEE |
| Tissue Specificity | Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas. |
| Post Translational Modifications | Glycosylated. The signal sequence is not cleaved. Present in two forms, form B contains a disulfide bond, form A does not. |
| Function | Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. |
| Protein Name | Serum Paraoxonase/Arylesterase 1Pon 1 Aromatic Esterase 1A-Esterase 1K-45Serum Aryldialkylphosphatase 1 |
| Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-9754706 |
| Cellular Localisation | SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Serum Paraoxonase/Arylesterase 1 antibodyAnti-Pon 1 antibodyAnti-Aromatic Esterase 1 antibodyAnti-A-Esterase 1 antibodyAnti-K-45 antibodyAnti-Serum Aryldialkylphosphatase 1 antibodyAnti-PON1 antibodyAnti-PON antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
