Anti-POMGNT1 antibody (411-660) (STJ111921)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal POMGNT1 (411-660) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | POMGNT1 |
| Gene ID | 55624 |
| Uniprot ID | PMGT1_HUMAN |
| Immunogen Region | 411-660 |
| Immunogen Sequence | HLLEEDDSLYCISAWNDQGY EHTAEDPALLYRVETMPGLG WVLRRSLYKEELEPKWPTPE KLWDWDMWMRMPEQRRGREC IIPDVSRSYHFGIVGLNMNG YFHEAYFKKHKFNTVPGVQL RNVDSLKKEAYEVEVHRLLS EAEVLDHSKNPCEDSFLPDT EGHTYVAFIRMEKDDDFTTW TQLAKCLHIWDLDVRGNHRG LWRLFRKKNHFLVVGVPASP YSVKKPPSVTPIFLEPPPK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 411-660 of human POMGNT1 (NP_060209.3). |
Additional Info
| Tissue Specificity | Constitutively expressed. An additional weaker band is also detected in spinal cord, lymph node, and trachea. Expressed especially in astrocytes. Also expressed in immature and mature neurons. |
| Function | Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity. |
| Protein Name | Protein O-Linked-Mannose Beta-1 -2-N-Acetylglucosaminyltransferase 1Pomgnt1Udp-Glcnac -Alpha-D-Mannoside Beta-1 -2-N-Acetylglucosaminyltransferase I.2Gnt I.2 |
| Database Links | Reactome: R-HSA-5083628Reactome: R-HSA-5173105 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Protein O-Linked-Mannose Beta-1 -2-N-Acetylglucosaminyltransferase 1 antibodyAnti-Pomgnt1 antibodyAnti-Udp-Glcnac -Alpha-D-Mannoside Beta-1 -2-N-Acetylglucosaminyltransferase I.2 antibodyAnti-Gnt I.2 antibodyAnti-POMGNT1 antibodyAnti-MGAT1.2 antibodyAnti-UNQ746 antibodyAnti-PRO1475 antibody |
Information sourced from Uniprot.org