| Short Description : | Rabbit polyclonal POLL (421-575) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | POLL |
| Gene ID: | 27343 |
| Uniprot ID: | DPOLL_HUMAN |
| Immunogen Region: | 421-575 |
| Immunogen Sequence: | GKATCGDVDVLITHPDGRSH RGIFSRLLDSLRQEGFLTDD LVSQEENGQQQKYLGVCRLP GPGRRHRRLDIIVVPYSEFA CALLYFTGSAHFNRSMRALA KTKGMSLSEHALSTAVVRNT HGCKVGPGRVLPTPTEKDVF RLLGLPYREPAERDW |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 421-575 of human POLL (NP_037406.1). |
| Tissue Specificity | Expressed in a number of tissues. Abundant in testis. |
| Function | DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Also has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. |
| Protein Name | Dna Polymerase LambdaPol LambdaDna Polymerase Beta-2Pol Beta2Dna Polymerase Kappa |
| Database Links | Reactome: R-HSA-5693571 |
| Cellular Localisation | NucleusChromosomeAccumulates At Sites Of Dna Damage |
| Alternative Antibody Names | Anti-Dna Polymerase Lambda antibodyAnti-Pol Lambda antibodyAnti-Dna Polymerase Beta-2 antibodyAnti-Pol Beta2 antibodyAnti-Dna Polymerase Kappa antibodyAnti-POLL antibody |
Information sourced from Uniprot.org
