Anti-PNPLA3 antibody (377-481) (STJ28777)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PNPLA3 (377-481) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PNPLA3 |
| Gene ID | 80339 |
| Uniprot ID | PLPL3_HUMAN |
| Immunogen Region | 377-481 |
| Immunogen Sequence | PDMPDDVLWLQWVTSQVFTR VLMCLLPASRSQMPVSSQQA SPCTPEQDWPCWTPCSPKGC PAETKAEATPRSILRSSLNF FLGNKVPAGAEGLSTFPSFS LEKSL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 377-481 of human PNPLA3 (NP_079501.2). |
Additional Info
| Function | Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA. Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides. In vitro may express hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety. However, the triacylglycerol hydrolase activity is controversial and may be very low. Possesses phospholipase A2 activity. |
| Protein Name | 1-Acylglycerol-3-Phosphate O-Acyltransferase Pnpla3Acylglycerol TransacylaseAdiponutrinAdpnCalcium-Independent Phospholipase A2-EpsilonIpla2-EpsilonLysophosphatidic Acid AcyltransferasePatatin-Like Phospholipase Domain-Containing Protein 3 |
| Database Links | Reactome: R-HSA-1482883 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane ProteinLipid Droplet |
| Alternative Antibody Names | Anti-1-Acylglycerol-3-Phosphate O-Acyltransferase Pnpla3 antibodyAnti-Acylglycerol Transacylase antibodyAnti-Adiponutrin antibodyAnti-Adpn antibodyAnti-Calcium-Independent Phospholipase A2-Epsilon antibodyAnti-Ipla2-Epsilon antibodyAnti-Lysophosphatidic Acid Acyltransferase antibodyAnti-Patatin-Like Phospholipase Domain-Containing Protein 3 antibodyAnti-PNPLA3 antibodyAnti-ADPN antibodyAnti-C22orf20 antibody |
Information sourced from Uniprot.org