Anti-PNPLA2 antibody (STJA0006777)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ATGL
General Information
| Short Description | Rabbit polyclonal anti-Patatin-like phospholipase domain-containing protein 2 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PNPLA2 |
| Gene ID | 57104 |
| Uniprot ID | PLPL2_HUMAN |
| Immunogen | Synthesized peptide derived from human ATGL |
| Specificity | This antibody detects endogenous levels of ATGL at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-404 by PKA is increased during fasting and moderate intensity exercise, and moderately increases lipolytic activity. Phosphorylation at Ser-404 is increased upon beta-adrenergic stimulation. Ubiquitinated by PEX2 in response to reactive oxygen species (ROS), leading to its degradation. Ubiquitination is stimulated by LDAH. |
| Function | Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade. Also possesses acylglycerol transacylase and phospholipase A2 activities. Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides. Regulates adiposome size and may be involved in the degradation of adiposomes. Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes. Acts antagonistically with LDAH in regulation of cellular lipid stores. Inhibits LDAH-stimulated lipid droplet fusion. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. |
| Protein Name | Patatin-Like Phospholipase Domain-Containing Protein 2Adipose Triglyceride LipaseCalcium-Independent Phospholipase A2-ZetaIpla2-ZetaDesnutrinPigment Epithelium-Derived Factor ReceptorPedf-RTts2.2Transport-Secretion Protein 2Tts2 |
| Database Links | Reactome: R-HSA-1482883Reactome: R-HSA-381426Reactome: R-HSA-8957275Reactome: R-HSA-9841922 |
| Cellular Localisation | Lipid DropletCell MembraneMulti-Pass Membrane ProteinCytoplasm |
| Alternative Antibody Names | Anti-Patatin-Like Phospholipase Domain-Containing Protein 2 antibodyAnti-Adipose Triglyceride Lipase antibodyAnti-Calcium-Independent Phospholipase A2-Zeta antibodyAnti-Ipla2-Zeta antibodyAnti-Desnutrin antibodyAnti-Pigment Epithelium-Derived Factor Receptor antibodyAnti-Pedf-R antibodyAnti-Tts2.2 antibodyAnti-Transport-Secretion Protein 2 antibodyAnti-Tts2 antibodyAnti-PNPLA2 antibodyAnti-ATGL antibodyAnti-FP17548 antibody |
Information sourced from Uniprot.org