Anti-PNN antibody (1-100) (STJ11102814)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PNN (1-100) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PNN |
| Gene ID | 5411 |
| Uniprot ID | PININ_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MAVAVRTLQEQLEKAKESLK NVDENIRKLTGRDPNDVRPI QARLLALSGPGGGRGRGSLL LRRGFSDSGGGPPAKQRDLE GAVSRLGGERRTRRESRQES |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PNN (NP_002678.2). |
Additional Info
| Tissue Specificity | Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors. |
| Function | Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene.the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma. |
| Protein Name | Pinin140 Kda Nuclear And Cell Adhesion-Related PhosphoproteinDesmosome-Associated ProteinDomain-Rich Serine ProteinDrs ProteinDrspMelanoma Metastasis Clone A ProteinNuclear Protein Sdk3Sr-Like Protein |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus SpeckleCell JunctionDesmosomeCell-Cell Contact AreaPredominantly Desmosome Of Intercellular Adherens JunctionNot A Nucleocytoplasmic Shuttling Protein |
| Alternative Antibody Names | Anti-Pinin antibodyAnti-140 Kda Nuclear And Cell Adhesion-Related Phosphoprotein antibodyAnti-Desmosome-Associated Protein antibodyAnti-Domain-Rich Serine Protein antibodyAnti-Drs Protein antibodyAnti-Drsp antibodyAnti-Melanoma Metastasis Clone A Protein antibodyAnti-Nuclear Protein Sdk3 antibodyAnti-Sr-Like Protein antibodyAnti-PNN antibodyAnti-DRS antibodyAnti-MEMA antibody |
Information sourced from Uniprot.org