Anti-PNLIPRP2 antibody (STJA0009113)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PNLIPRP2
General Information
| Short Description | Rabbit polyclonal anti-Pancreatic lipase-related protein 2 for use in WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PNLIPRP2 |
| Gene ID | 5408 |
| Uniprot ID | LIPR2_HUMAN |
| Immunogen | Synthesized peptide derived from human PNLIPRP2 |
| Specificity | This antibody detects endogenous levels of PNLIPRP2 at Human, Rat |
Additional Info
| Function | Lipase that primarily hydrolyzes triglycerides and galactosylglycerides. In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides. Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity. Can completely deacylate triacylglycerols. When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids. Hydrolyzes medium- and long-chain fatty acyls in galactolipids. May act together with LIPF to hydrolyze partially digested triglycerides. Hydrolyzes long-chain monoglycerides with high efficiency. In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity. Also has low phospholipase activity. In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids. The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane. |
| Protein Name | Pancreatic Lipase-Related Protein 2Pl-Rp2Cytotoxic T Lymphocyte LipaseGalactolipaseTriacylglycerol Lipase |
| Database Links | Reactome: R-HSA-192456Reactome: R-HSA-9925561 |
| Cellular Localisation | SecretedZymogen Granule MembranePeripheral Membrane ProteinCell ProjectionNeuron ProjectionLocalizes To Neurite Tips In Neuronal Cells |
| Alternative Antibody Names | Anti-Pancreatic Lipase-Related Protein 2 antibodyAnti-Pl-Rp2 antibodyAnti-Cytotoxic T Lymphocyte Lipase antibodyAnti-Galactolipase antibodyAnti-Triacylglycerol Lipase antibodyAnti-PNLIPRP2 antibodyAnti-PLRP2 antibody |
Information sourced from Uniprot.org