| Post Translational Modifications | Ubiquitinated by PEX2 during pexophagy in response to starvation, leading to its degradation. |
| Function | Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation. Has fatty acyl-CoA thioesterase and ATPase activities. Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes. Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation. |
| Protein Name | Atp-Binding Cassette Sub-Family D Member 370 Kda Peroxisomal Membrane ProteinPmp70 |
| Database Links | Reactome: R-HSA-1369062Reactome: R-HSA-8980692Reactome: R-HSA-9013106Reactome: R-HSA-9603798 |
| Cellular Localisation | Peroxisome MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family D Member 3 antibodyAnti-70 Kda Peroxisomal Membrane Protein antibodyAnti-Pmp70 antibodyAnti-ABCD3 antibodyAnti-PMP70 antibodyAnti-PXMP1 antibody |
Information sourced from Uniprot.org
