Anti-PMAIP1 antibody (STJA0009777)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Noxa
General Information
| Short Description | Rabbit polyclonal anti-Phorbol-12-myristate-13-acetate-induced protein 1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PMAIP1 |
| Gene ID | 5366 |
| Uniprot ID | APR_HUMAN |
| Immunogen | Synthesized peptide derived from human Noxa |
| Specificity | This antibody detects endogenous levels of Noxa at Human, Mouse, Rat |
Additional Info
| Function | Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. |
| Protein Name | Phorbol-12-Myristate-13-Acetate-Induced Protein 1Pma-Induced Protein 1Immediate-Early-Response Protein AprProtein Noxa |
| Database Links | Reactome: R-HSA-111448Reactome: R-HSA-111453Reactome: R-HSA-6803204 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 antibodyAnti-Pma-Induced Protein 1 antibodyAnti-Immediate-Early-Response Protein Apr antibodyAnti-Protein Noxa antibodyAnti-PMAIP1 antibodyAnti-NOXA antibody |
Information sourced from Uniprot.org