Anti-PLVAP antibody (63-442) (STJ118351)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PLVAP (63-442) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLVAP |
| Gene ID | 83483 |
| Uniprot ID | PLVAP_HUMAN |
| Immunogen Region | 63-442 |
| Immunogen Sequence | TERRAEGLYSQLLGLTASQS NLTKELNFTTRAKDAIMQMW LNARRDLDRINASFRQCQGD RVIYTNNQRYMAAIILSEKQ CRDQFKDMNKSCDALLFMLN QKVKTLEVEIAKEKTICTKD KESVLLNKRVAEEQLVECVK TRELQHQERQLAKEQLQKVQ ALCLPLDKDKFEMDLRNLWR DSIIPRSLDNLGYNLYHPLG SELASIRRACDHMPSLMSSK VEELARSLRADIERVAREN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 63-442 of human PLVAP (NP_112600.1). |
Additional Info
| Tissue Specificity | Expressed in lung, kidney, heart, aorta, placenta, muscle, pituitary gland, adrenals, mammary gland, bladder, lymph node, bone marrow, trachea, digestive tract, liver and tumor-associated endothelium. |
| Function | Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development. |
| Protein Name | Plasmalemma Vesicle-Associated ProteinFenestrated Endothelial-Linked Structure ProteinPlasmalemma Vesicle Protein 1Pv-1 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinMembraneCaveolaCytoplasmPerinuclear RegionMembrane-Associated Protein Of CaveolaeFound In Fenestral And Stomatal Diaphragms In Fenestrated Endothelia And Transendothelial ChannelsAlso Colocalized With Cav1 In Perinuclear Region |
| Alternative Antibody Names | Anti-Plasmalemma Vesicle-Associated Protein antibodyAnti-Fenestrated Endothelial-Linked Structure Protein antibodyAnti-Plasmalemma Vesicle Protein 1 antibodyAnti-Pv-1 antibodyAnti-PLVAP antibodyAnti-FELS antibodyAnti-PV1 antibody |
Information sourced from Uniprot.org