Anti-PLSCR3 antibody (180-260 aa) (STJ191162)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 180-260
General Information
| Short Description | Rabbit polyclonal anti-Phospholipid scramblase 3-dependent phospholipid scramblase 3 (180-260 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLSCR3 |
| Gene ID | 57048 |
| Uniprot ID | PLS3_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 180-260 |
| Immunogen Region | 180-260 aa |
| Specificity | PLS3 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylation at Thr-21 by PKC/PRKCD upon apoptotic stimuli enhances phospholipid scramblase activity. Palmitoylation regulates its localization to the cell membrane or the nucleus.trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus. |
| Function | Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria. Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response. Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis. Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases. Regulates cardiolipin de novo biosynthesis and its resynthesis. |
| Protein Name | Phospholipid Scramblase 3Pl Scramblase 3Ca(2+-Dependent Phospholipid Scramblase 3 |
| Database Links | |
| Cellular Localisation | Mitochondrion MembraneSingle-Pass Type Ii Membrane ProteinMitochondrion Inner MembraneNucleusPalmitoylation Regulates Its Localization To The Cell Membrane Or The NucleusTrafficking To The Cell Membrane Is Dependent Upon Palmitoylation Whereas In The Absence Of PalmitoylationLocalizes To The Nucleus |
| Alternative Antibody Names | Anti-Phospholipid Scramblase 3 antibodyAnti-Pl Scramblase 3 antibodyAnti-Ca(2+-Dependent Phospholipid Scramblase 3 antibodyAnti-PLSCR3 antibody |
Information sourced from Uniprot.org