| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospholipid scramblase 3-dependent phospholipid scramblase 3 (180-260 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLSCR3 |
| Gene ID: |
57048 |
| Uniprot ID: |
PLS3_HUMAN |
| Immunogen Region: |
180-260 aa |
| Specificity: |
PLS3 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 180-260 |
| Post Translational Modifications | Phosphorylation at Thr-21 by PKC/PRKCD upon apoptotic stimuli enhances phospholipid scramblase activity. Palmitoylation regulates its localization to the cell membrane or the nucleus.trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus. |
| Function | Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria. Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response. Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis. Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases. Regulates cardiolipin de novo biosynthesis and its resynthesis. |
| Protein Name | Phospholipid Scramblase 3Pl Scramblase 3Ca(2+-Dependent Phospholipid Scramblase 3 |
| Cellular Localisation | Mitochondrion MembraneSingle-Pass Type Ii Membrane ProteinMitochondrion Inner MembraneNucleusPalmitoylation Regulates Its Localization To The Cell Membrane Or The NucleusTrafficking To The Cell Membrane Is Dependent Upon Palmitoylation Whereas In The Absence Of PalmitoylationLocalizes To The Nucleus |
| Alternative Antibody Names | Anti-Phospholipid Scramblase 3 antibodyAnti-Pl Scramblase 3 antibodyAnti-Ca(2+-Dependent Phospholipid Scramblase 3 antibodyAnti-PLSCR3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
