| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (145-195 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLPP6 |
| Gene ID: |
403313 |
| Uniprot ID: |
PLPP6_HUMAN |
| Immunogen Region: |
145-195 aa |
| Specificity: |
This antibody detects endogenous levels of PPAC2 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human PPAC2 at the amino acid range 145-195 |
| Post Translational Modifications | Phosphorylation by PKC activates the phosphatase activity towards presqualene diphosphate. |
| Function | Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates. Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation. May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway. May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins. Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols. May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate. |
| Protein Name | Polyisoprenoid Diphosphate/Phosphate Phosphohydrolase Plpp6 Lipid Phosphatase-Related Protein-BLprp-BPa-PspPhosphatidic Acid Phosphatase Type 2 Domain-Containing Protein 2Ppap2 Domain-Containing Protein 2Phospholipid Phosphatase 6Presqualene Diphosphate PhosphataseType 1 Polyisoprenoid Diphosphate Phosphatase |
| Database Links | Reactome: R-HSA-191273 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinNucleus EnvelopeNucleus Inner Membrane |
| Alternative Antibody Names | Anti-Polyisoprenoid Diphosphate/Phosphate Phosphohydrolase Plpp6 antibodyAnti-Lipid Phosphatase-Related Protein-B antibodyAnti-Lprp-B antibodyAnti-Pa-Psp antibodyAnti-Phosphatidic Acid Phosphatase Type 2 Domain-Containing Protein 2 antibodyAnti-Ppap2 Domain-Containing Protein 2 antibodyAnti-Phospholipid Phosphatase 6 antibodyAnti-Presqualene Diphosphate Phosphatase antibodyAnti-Type 1 Polyisoprenoid Diphosphate Phosphatase antibodyAnti-PLPP6 antibodyAnti-PDP1 antibodyAnti-PPAPDC2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
