Anti-PLIN1 antibody (STJA0009775)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Perilipin-1
General Information
| Short Description | Rabbit polyclonal anti-Perilipin-1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLIN1 |
| Gene ID | 5346 |
| Uniprot ID | PLIN1_HUMAN |
| Immunogen | Synthesized peptide derived from human Perilipin-1 |
| Specificity | This antibody detects endogenous levels of Perilipin-1 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet. |
| Function | Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. |
| Protein Name | Perilipin-1Lipid Droplet-Associated Protein |
| Database Links | Reactome: R-HSA-163560Reactome: R-HSA-381340Reactome: R-HSA-9031528Reactome: R-HSA-9841922 |
| Cellular Localisation | Endoplasmic ReticulumLipid DropletLipid Droplet Surface-Associated |
| Alternative Antibody Names | Anti-Perilipin-1 antibodyAnti-Lipid Droplet-Associated Protein antibodyAnti-PLIN1 antibodyAnti-PERI antibodyAnti-PLIN antibody |
Information sourced from Uniprot.org