Anti-Plectin antibody [SRM14415] (STJ11109145)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal Plectin antibody for use in IHC-P and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM14415 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | IHC-P, 1:50-1:200ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLEC |
| Gene ID | 5339 |
| Uniprot ID | PLEC_HUMAN |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
Additional Info
| Tissue Specificity | Widely expressed with highest levels in muscle, heart, placenta and spinal cord. |
| Post Translational Modifications | Phosphorylated by CDK1.regulates dissociation from intermediate filaments during mitosis. |
| Function | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. |
| Protein Name | PlectinPcnPltnHemidesmosomal Protein 1Hd1Plectin-1 |
| Database Links | Reactome: R-HSA-2022090Reactome: R-HSA-264870Reactome: R-HSA-446107 |
| Cellular Localisation | CytoplasmCytoskeletonCell JunctionHemidesmosomeCell ProjectionPodosomeLocalized To The Cortex Of Myotube Podosomes |
| Alternative Antibody Names | Anti-Plectin antibodyAnti-Pcn antibodyAnti-Pltn antibodyAnti-Hemidesmosomal Protein 1 antibodyAnti-Hd1 antibodyAnti-Plectin-1 antibodyAnti-PLEC antibodyAnti-PLEC1 antibody |
Information sourced from Uniprot.org