| Function | 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor. Involved in phagocytosis of activated microglia. |
| Protein Name | 5'-3' Exonuclease Pld4Choline Phosphatase 4Phosphatidylcholine-Hydrolyzing Phospholipase D4Phospholipase D Family Member 4Phospholipase D4Pld 4 |
| Database Links | Reactome: R-HSA-1483148Reactome: R-HSA-1855204Reactome: R-HSA-2029485 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinGolgi ApparatusTrans-Golgi Network MembraneNucleusEarly EndosomeCytoplasmic VesiclePhagosomeActivation Of Microglia Induces Translocation Of Pld4 From The Nucleus To The Phagosomes |
| Alternative Antibody Names | Anti-5'-3' Exonuclease Pld4 antibodyAnti-Choline Phosphatase 4 antibodyAnti-Phosphatidylcholine-Hydrolyzing Phospholipase D4 antibodyAnti-Phospholipase D Family Member 4 antibodyAnti-Phospholipase D4 antibodyAnti-Pld 4 antibodyAnti-PLD4 antibodyAnti-C14orf175 antibodyAnti-UNQ2488 antibodyAnti-PRO5775 antibody |
Information sourced from Uniprot.org
