| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase zeta-1 (520-570 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLCZ1 |
| Gene ID: |
89869 |
| Uniprot ID: |
PLCZ1_HUMAN |
| Immunogen Region: |
520-570 aa |
| Specificity: |
This antibody detects endogenous levels of human PLCZ1 |
| Immunogen: |
Synthesized peptide derived from the human PLCZ1 at the amino acid range 520-570 |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Zeta-1Phosphoinositide Phospholipase C-Zeta-1Phospholipase C-Zeta-1Plc-Zeta-1Testis-Development Protein Nyd-Sp27 |
| Database Links | Reactome: R-HSA-1855204 |
| Cellular Localisation | NucleusCytoplasmPerinuclear RegionExhibits Alternative Cytoplasmic/Nuclear Localization During DevelopmentTranslocates From The Pronucleus Into Cytoplasm Upon Nuclear Envelope Breakdown For Mitosis And Localizes Again To The Pronucleus At Interphase Following Meiosis And Mitosis |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Zeta-1 antibodyAnti-Phosphoinositide Phospholipase C-Zeta-1 antibodyAnti-Phospholipase C-Zeta-1 antibodyAnti-Plc-Zeta-1 antibodyAnti-Testis-Development Protein Nyd-Sp27 antibodyAnti-PLCZ1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
