Anti-PLCG2 antibody (701-800) [S5529RM] (STJ11105529)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal 1-Phosphatidylinositol 4-5-Bisphosphate Phosphodiesterase Gamma-2 (701-800) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5529RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLCG2 |
| Gene ID | 5336 |
| Uniprot ID | PLCG2_HUMAN |
| Immunogen Region | 701-800 |
| Immunogen Sequence | HFVLGTSAYFESLVELVSYY EKHSLYRKMRLRYPVTPELL ERYNMERDINSLYDVSRMYV DPSEINPSMPQRTVKALYDY KAKRSDELSFCRGALIHNVS |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 701-800 of PLC gamma 2 (PLCG2) (NP_002652.2) |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues by CSF1R. Phosphorylated on tyrosine residues by BTK and SYK.upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity. |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-2Phosphoinositide Phospholipase C-Gamma-2Phospholipase C-IvPlc-IvPhospholipase C-Gamma-2Plc-Gamma-2 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-166016Reactome: R-HSA-1855204Reactome: R-HSA-202433Reactome: R-HSA-2029485Reactome: R-HSA-2424491Reactome: R-HSA-2871796Reactome: R-HSA-2871809Reactome: R-HSA-5607764Reactome: R-HSA-5621480Reactome: R-HSA-9027277Reactome: R-HSA-9664323Reactome: R-HSA-9679191Reactome: R-HSA-9680350Reactome: R-HSA-983695 |
| Cellular Localisation | Membrane Raft |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-2 antibodyAnti-Phosphoinositide Phospholipase C-Gamma-2 antibodyAnti-Phospholipase C-Iv antibodyAnti-Plc-Iv antibodyAnti-Phospholipase C-Gamma-2 antibodyAnti-Plc-Gamma-2 antibodyAnti-PLCG2 antibody |
Information sourced from Uniprot.org