Anti-PLCG1 antibody (736-785 aa) (STJ95157)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human PLCG1 at the amino acid range 736-785
General Information
| Short Description | Rabbit polyclonal anti-1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma-1 (736-785 aa) for use in WB, IHC, IF and ELISA in Human, Mouse, Rat and Monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat/Monkey |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLCG1 |
| Gene ID | 5335 |
| Uniprot ID | PLCG1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human PLCG1 at the amino acid range 736-785 |
| Immunogen Region | 736-785 aa |
| Specificity | PLC Gamma 1 Polyclonal Antibody detects endogenous levels of PLC Gamma 1 protein. |
Additional Info
| Function | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-1Plc-148Phosphoinositide Phospholipase C-Gamma-1Phospholipase C-IiPlc-IiPhospholipase C-Gamma-1Plc-Gamma-1 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-1236382Reactome: R-HSA-1251932Reactome: R-HSA-1489509Reactome: R-HSA-167021Reactome: R-HSA-1855204Reactome: R-HSA-186763Reactome: R-HSA-201556Reactome: R-HSA-202433Reactome: R-HSA-2029485Reactome: R-HSA-210990Reactome: R-HSA-212718Reactome: R-HSA-2424491Reactome: R-HSA-2871796Reactome: R-HSA-2871809Reactome: R-HSA-418890Reactome: R-HSA-5218921Reactome: R-HSA-5637810Reactome: R-HSA-5654219Reactome: R-HSA-5654221Reactome: R-HSA-5654227Reactome: R-HSA-5654228Reactome: R-HSA-5655253Reactome: R-HSA-5655291Reactome: R-HSA-5655302Reactome: R-HSA-5655332Reactome: R-HSA-8853659Reactome: R-HSA-9026527Reactome: R-HSA-9027277Reactome: R-HSA-9034793Reactome: R-HSA-9664323Reactome: R-HSA-9664565Reactome: R-HSA-9665348Reactome: R-HSA-9665686Reactome: R-HSA-9725370 |
| Cellular Localisation | Cell ProjectionLamellipodiumRuffleRapidly Redistributed To Ruffles And Lamellipodia Structures In Response To Epidermal Growth Factor (Egf) Treatment |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-1 antibodyAnti-Plc-148 antibodyAnti-Phosphoinositide Phospholipase C-Gamma-1 antibodyAnti-Phospholipase C-Ii antibodyAnti-Plc-Ii antibodyAnti-Phospholipase C-Gamma-1 antibodyAnti-Plc-Gamma-1 antibodyAnti-PLCG1 antibodyAnti-PLC1 antibody |
Information sourced from Uniprot.org