| Host: |
Rabbit |
| Applications: |
IHC/IF |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase epsilon-1 is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC-P 1:50-300IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLCE1 |
| Gene ID: |
51196 |
| Uniprot ID: |
PLCE1_HUMAN |
| Specificity: |
PLCE1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Epsilon-1Pancreas-Enriched Phospholipase CPhosphoinositide Phospholipase C-Epsilon-1Phospholipase C-Epsilon-1Plc-Epsilon-1 |
| Database Links | Reactome: R-HSA-1855204 |
| Cellular Localisation | CytoplasmCytosolCell MembraneGolgi Apparatus MembraneCell ProjectionLamellipodiumRecruited To Plasma Membrane By Activated Hras And Rap2Recruited To Perinuclear Membrane By Activated Rap1aIsoform 1 And Isoform 2 Associates With Golgi Membranes |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Epsilon-1 antibodyAnti-Pancreas-Enriched Phospholipase C antibodyAnti-Phosphoinositide Phospholipase C-Epsilon-1 antibodyAnti-Phospholipase C-Epsilon-1 antibodyAnti-Plc-Epsilon-1 antibodyAnti-PLCE1 antibodyAnti-KIAA1516 antibodyAnti-PLCE antibodyAnti-PPLC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
