Anti-PLCE1 antibody (STJ191893)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase epsilon-1 for use in IHC and IF in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-300IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLCE1 |
| Gene ID | 51196 |
| Uniprot ID | PLCE1_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | PLCE1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Epsilon-1Pancreas-Enriched Phospholipase CPhosphoinositide Phospholipase C-Epsilon-1Phospholipase C-Epsilon-1Plc-Epsilon-1 |
| Database Links | Reactome: R-HSA-1855204 |
| Cellular Localisation | CytoplasmCytosolCell MembraneGolgi Apparatus MembraneCell ProjectionLamellipodiumRecruited To Plasma Membrane By Activated Hras And Rap2Recruited To Perinuclear Membrane By Activated Rap1aIsoform 1 And Isoform 2 Associates With Golgi Membranes |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Epsilon-1 antibodyAnti-Pancreas-Enriched Phospholipase C antibodyAnti-Phosphoinositide Phospholipase C-Epsilon-1 antibodyAnti-Phospholipase C-Epsilon-1 antibodyAnti-Plc-Epsilon-1 antibodyAnti-PLCE1 antibodyAnti-KIAA1516 antibodyAnti-PLCE antibodyAnti-PPLC antibody |
Information sourced from Uniprot.org