Anti-PLCD3 antibody (501-551 aa) (STJ195072)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human PLCD3 at the amino acid range 501-551
General Information
| Short Description | Rabbit polyclonal anti-1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase delta-3 (501-551 aa) for use in WB and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLCD3 |
| Gene ID | 113026 |
| Uniprot ID | PLCD3_HUMAN |
| Immunogen | Synthesized peptide derived from the human PLCD3 at the amino acid range 501-551 |
| Immunogen Region | 501-551 aa |
| Specificity | This antibody detects endogenous levels of PLCD3 at Human/Mouse |
Additional Info
| Function | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Delta-3Phosphoinositide Phospholipase C-Delta-3Phospholipase C-Delta-3Plc-Delta-3 |
| Database Links | Reactome: R-HSA-1855204 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmCleavage FurrowLocalizes At The Cleavage Furrow During Cytokinesis |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Delta-3 antibodyAnti-Phosphoinositide Phospholipase C-Delta-3 antibodyAnti-Phospholipase C-Delta-3 antibodyAnti-Plc-Delta-3 antibodyAnti-PLCD3 antibodyAnti-KIAA1964 antibody |
Information sourced from Uniprot.org