Anti-PLCB1 antibody [R39-2S-8] (STJA0035596)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human PLCB1
General Information
| Short Description | Rabbit monoclonal anti-PLCB1 for use in WB and IHC-P in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R39-2S-8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:100-1:200 |
| Formulation | Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PLCB1 |
| Gene ID | 23236 |
| Uniprot ID | PLCB1_HUMAN |
| Immunogen | A synthesized peptide derived from human PLCB1 |
Additional Info
| Post Translational Modifications | Palmitoylated. Palmitoylation at Cys-17 by ZDHHC21 regulates the signaling activity of PLCB1 and the function of the endothelial barrier. Palmitoylation by ZDHHC21 is stimulated by inflammation. |
| Function | Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-1Plc-154Phosphoinositide Phospholipase C-Beta-1Phospholipase C-IPlc-IPhospholipase C-Beta-1Plc-Beta-1 |
| Database Links | Reactome: R-HSA-112043Reactome: R-HSA-1855204Reactome: R-HSA-399997Reactome: R-HSA-4086398Reactome: R-HSA-416476Reactome: R-HSA-418217Reactome: R-HSA-434316Reactome: R-HSA-500657 |
| Cellular Localisation | Nucleus MembraneCytoplasmColocalizes With The Adrenergic ReceptorsAdren1a And Adren1bAt The Nuclear Membrane Of Cardiac Myocytes |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-1 antibodyAnti-Plc-154 antibodyAnti-Phosphoinositide Phospholipase C-Beta-1 antibodyAnti-Phospholipase C-I antibodyAnti-Plc-I antibodyAnti-Phospholipase C-Beta-1 antibodyAnti-Plc-Beta-1 antibodyAnti-PLCB1 antibodyAnti-KIAA0581 antibody |
Information sourced from Uniprot.org