Anti-PLAUR antibody (100-200) [PT2194] (STJA0006241)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2bk
ImmunogenSynthesized peptide derived from human uPAR AA range: 100-200
General Information
| Short Description | Mouse monoclonal anti-Urokinase plasminogen activator surface receptor (100-200) for use in WB and ELISA in Human, Chicken and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Mouse |
| Reactivity | Human/Chicken/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | PT2194 |
| Isotype | IgG2bk |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLAUR |
| Gene ID | 5329 |
| Uniprot ID | UPAR_HUMAN |
| Immunogen | Synthesized peptide derived from human uPAR AA range: 100-200 |
| Immunogen Region | 100-200 |
| Specificity | This antibody detects endogenous levels of uPAR at H, CHLAE;Not M, R |
Additional Info
| Tissue Specificity | Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain. |
| Function | Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. |
| Protein Name | Urokinase Plasminogen Activator Surface ReceptorU-ParUparMonocyte Activation Antigen Mo3Cd Antigen Cd87 |
| Database Links | Reactome: R-HSA-162791Reactome: R-HSA-6798695Reactome: R-HSA-75205 |
| Cellular Localisation | Cell MembraneCell ProjectionInvadopodium MembraneColocalized With Fap (Seprase) Preferentially At The Cell Surface Of Invadopodia Membrane In A Cytoskeleton-Integrin- And Vitronectin-Dependent MannerIsoform 1: Cell MembraneLipid-AnchorGpi-AnchorIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Urokinase Plasminogen Activator Surface Receptor antibodyAnti-U-Par antibodyAnti-Upar antibodyAnti-Monocyte Activation Antigen Mo3 antibodyAnti-Cd Antigen Cd87 antibodyAnti-PLAUR antibodyAnti-MO3 antibodyAnti-UPAR antibody |
Information sourced from Uniprot.org