• Western blot analysis of various lysates using PLAU Rabbit polyclonal antibody (STJ25021) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-PLAU antibody (20-180) (STJ25021)

SKU:
STJ25021

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PLAU (20-180) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PLAU
Gene ID: 5328
Uniprot ID: UROK_HUMAN
Immunogen Region: 20-180
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-180 of human PLAU (NP_002649.1).
Immunogen Sequence: GSNELHQVPSNCDCLNGGTC VSNKYFSNIHWCNCPKKFGG QHCEIDKSKTCYEGNGHFYR GKASTDTMGRPCLPWNSATV LQQTYHAHRSDALQLGLGKH NYCRNPDNRRRPWCYVQVGL KPLVQECMVHDCADGKKPSS PPEELKFQCGQKTLRPRFKI I
Tissue Specificity Expressed in the prostate gland and prostate cancers.
Post Translational Modifications Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding. Produced as an inactive single-chain protein (pro-uPA or sc-uPA), is processed into the active disulfide-linked two-chain form of PLAU/uPA by a proteolytic event mediated, at least, by TMPRSS4.
Function Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Protein Name Urokinase-Type Plasminogen Activator
U-Plasminogen Activator
Upa Cleaved Into - Urokinase-Type Plasminogen Activator Long Chain A - Urokinase-Type Plasminogen Activator Short Chain A - Urokinase-Type Plasminogen Activator Chain B
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-75205
Cellular Localisation Secreted
Alternative Antibody Names Anti-Urokinase-Type Plasminogen Activator antibody
Anti-U-Plasminogen Activator antibody
Anti-Upa Cleaved Into - Urokinase-Type Plasminogen Activator Long Chain A - Urokinase-Type Plasminogen Activator Short Chain A - Urokinase-Type Plasminogen Activator Chain B antibody
Anti-PLAU antibody

Information sourced from Uniprot.org

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