![Anti-PLAP antibody [NB-10] (STJ16100416)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149133/346754/STJ16100416_1__78027.1681998850.jpg?c=1 "Anti-PLAP antibody [NB-10] (STJ16100416)")
![Anti-PLAP antibody [NB-10] (STJ16100416)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149133/346754/STJ16100416_1__78027.1681998850.jpg?c=1 "Anti-PLAP antibody [NB-10] (STJ16100416)")
Anti-PLAP antibody [NB-10] (STJ16100416)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal anti-PLAP for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | NB-10 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Dilution Range | IHC 1:50 – 1:200 |
| Formulation | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | PLAA |
| Gene ID | 9373 |
| Uniprot ID | PLAP_HUMAN |
Additional Info
| Function | Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis. |
| Protein Name | Phospholipase A-2-Activating ProteinPla2pPlap |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmSynapseRecruited To Damaged Lysosomes Decorated With K48-Linked Ubiquitin Chains |
| Alternative Antibody Names | Anti-Phospholipase A-2-Activating Protein antibodyAnti-Pla2p antibodyAnti-Plap antibodyAnti-PLAA antibodyAnti-PLAP antibody |
Information sourced from Uniprot.org