Anti-PLAP antibody [IHC088] (STJA0042247)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
General Information
| Short Description | Rabbit monoclonal anti-PLAP for use in IHC-p in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-p |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | IHC088 |
| Conjugation | Unconjugated |
| Formulation | Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide |
| Storage Instruction | Store at 2-8°C for up to 1 year. Do not freeze. |
Target Information
| Gene Symbol | PLAA |
| Gene ID | 9373 |
| Uniprot ID | PLAP_HUMAN |
| Specificity | Tested and validated on placenta tissue. |
Additional Info
| Function | Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis. |
| Protein Name | Phospholipase A-2-Activating ProteinPla2pPlap |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmSynapseRecruited To Damaged Lysosomes Decorated With K48-Linked Ubiquitin Chains |
| Alternative Antibody Names | Anti-Phospholipase A-2-Activating Protein antibodyAnti-Pla2p antibodyAnti-Plap antibodyAnti-PLAA antibodyAnti-PLAP antibody |
Information sourced from Uniprot.org