Anti-PLAG1 antibody (STJA0008904)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PLAG1
General Information
| Short Description | Rabbit polyclonal anti-Zinc finger protein PLAG1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLAG1 |
| Gene ID | 5324 |
| Uniprot ID | PLAG1_HUMAN |
| Immunogen | Synthesized peptide derived from human PLAG1 |
| Specificity | This antibody detects endogenous levels of PLAG1 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Sumoylated with SUMO1.which inhibits transcriptional activity, but does not affect nuclear localization. Blockers of sumoylation pathway such as SENP3 and inactive UBE2I increases transcriptional capacity. Sumoylation is increased in the presence of PIAS1. Acetylated by lysine acetyltransferase EP300.which activates transcriptional capacity. Lysine residues that are sumoylated also seem to be target for acetylation. |
| Function | Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia. |
| Protein Name | Zinc Finger Protein Plag1Pleiomorphic Adenoma Gene 1 Protein |
| Database Links | |
| Cellular Localisation | NucleusStrong Nucleolar Localization When Sumoylation Is Inhibited |
| Alternative Antibody Names | Anti-Zinc Finger Protein Plag1 antibodyAnti-Pleiomorphic Adenoma Gene 1 Protein antibodyAnti-PLAG1 antibody |
Information sourced from Uniprot.org