| Function | Calcium-dependent phospholipase A1 and A2 and lysophospholipase that may play a role in membrane phospholipid remodeling. Isoform 3: Calcium-dependent phospholipase A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-2 position of phosphatidylethanolamines, producing lysophospholipids that may be used in deacylation-reacylation cycles. Hydrolyzes lysophosphatidylcholines with low efficiency but is inefficient toward phosphatidylcholines. Isoform 5: Calcium-dependent phospholipase A1 and A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-1 or sn-2 position of diacyl phospholipids (phospholipase A1 and A2 activity, respectively), producing lysophospholipids that may be used in deacylation-reacylation cycles. Can further hydrolyze lysophospholipids enabling complete deacylation. Has no activity toward alkylacyl phospholipids. |
| Protein Name | Cytosolic Phospholipase A2 BetaCpla2-BetaLysophospholipase A1 Group IvbPhospholipase A2 Group Ivb |
| Database Links | Reactome: R-HSA-1482788Reactome: R-HSA-1482801Reactome: R-HSA-1482839Reactome: R-HSA-1482925Reactome: R-HSA-1483115Reactome: R-HSA-1483166Reactome: R-HSA-381038 |
| Cellular Localisation | Isoform 3: CytoplasmCytosolMitochondrion MembranePeripheral Membrane ProteinEarly Endosome MembraneTranslocates To Membrane Vesicles In A Calcium-Dependent FashionIsoform 5: Cytoplasm |
| Alternative Antibody Names | Anti-Cytosolic Phospholipase A2 Beta antibodyAnti-Cpla2-Beta antibodyAnti-Lysophospholipase A1 Group Ivb antibodyAnti-Phospholipase A2 Group Ivb antibodyAnti-PLA2G4B antibody |
Information sourced from Uniprot.org
