Anti-PLA2G1B antibody (70-150 aa) (STJ191159)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 70-150
General Information
| Short Description | Rabbit polyclonal anti-Phospholipase A2 (70-150 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLA2G1B |
| Gene ID | 5319 |
| Uniprot ID | PA21B_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 70-150 |
| Immunogen Region | 70-150 aa |
| Specificity | PA21B Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically. |
| Function | Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. May act in an autocrine and paracrine manner. Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis. Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity. |
| Protein Name | Phospholipase A2Group Ib Phospholipase A2Phosphatidylcholine 2-Acylhydrolase 1b |
| Database Links | Reactome: R-HSA-1482788Reactome: R-HSA-1482801Reactome: R-HSA-1482839Reactome: R-HSA-1482922Reactome: R-HSA-1482925Reactome: R-HSA-1483166Reactome: R-HSA-9925561 |
| Cellular Localisation | SecretedSecreted From Pancreatic Acinar Cells In Its Inactive Form |
| Alternative Antibody Names | Anti-Phospholipase A2 antibodyAnti-Group Ib Phospholipase A2 antibodyAnti-Phosphatidylcholine 2-Acylhydrolase 1b antibodyAnti-PLA2G1B antibodyAnti-PLA2 antibodyAnti-PLA2A antibodyAnti-PPLA2 antibody |
Information sourced from Uniprot.org