Anti-PLA2G15 antibody (STJA0004610)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFusion protein of human PLA2G15
General Information
| Short Description | Rabbit polyclonal anti-Phospholipase A2 Group Xv for use in IHC and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1.14 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | IHC 1:50-1:200 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | PLA2G15 |
| Gene ID | 23659 |
| Uniprot ID | PAG15_HUMAN |
| Immunogen | Fusion protein of human PLA2G15 |
Additional Info
| Tissue Specificity | Detected in blood plasma (at protein level). Ubiquitous. Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. |
| Post Translational Modifications | N-glycosylated. N-glycosylation is important for maturation of the enzyme and normal subcellular location. |
| Function | Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments. Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity). Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines. Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines, phosphatidylethanolamines, and phosphatidylglycerols. Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide. Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress. Required for normal phospholipid degradation in alveolar macrophages with potential implications in the clearance of pulmonary surfactant, which is mainly composed of dipalmitoylphosphatidylcholine (1,2-dihexadecanoyl-sn-glycero-3-phosphocholine). Involved in the first step of bis(monoacylglycero)phosphate (BMP) de novo synthesis from phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG). BMP is an important player in cargo sorting and degradation, regulation of cellular cholesterol levels and intercellular communication. At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines. |
| Protein Name | Lysosomal Phospholipase A And Acyltransferase 1-O-Acylceramide SynthaseAcsLcat-Like LysophospholipaseLlplLysophospholipase 3Lysosomal Phospholipase A2Lpla2Phospholipase A2 Group XvPla2g15 |
| Database Links | Reactome: R-HSA-1483115 |
| Cellular Localisation | LysosomeSecretedMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Lysosomal Phospholipase A And Acyltransferase antibodyAnti-1-O-Acylceramide Synthase antibodyAnti-Acs antibodyAnti-Lcat-Like Lysophospholipase antibodyAnti-Llpl antibodyAnti-Lysophospholipase 3 antibodyAnti-Lysosomal Phospholipase A2 antibodyAnti-Lpla2 antibodyAnti-Phospholipase A2 Group Xv antibodyAnti-Pla2g15 antibodyAnti-PLA2G15 antibodyAnti-LYPLA3 antibodyAnti-UNQ341 antibodyAnti-PRO540 antibody |
Information sourced from Uniprot.org