• Western blot analysis of HepG2 cells using Plakophilin 2 Polyclonal Antibody diluted at 1：500 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).
  • Western blot analysis of lysates from HeLa and HepG2 cells, using PKP2 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Plakophilin 2 Polyclonal Antibody diluted at 1：500 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Anti-PKP2 antibody (632-681 aa) (STJ95149)

SKU:
STJ95149

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/ELISA/IHC
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Plakophilin-2 (632-681 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-P 1:50-300
ELISA 2000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PKP2
Gene ID: 5318
Uniprot ID: PKP2_HUMAN
Immunogen Region: 632-681 aa
Specificity: Plakophilin 2 Polyclonal Antibody detects endogenous levels of Plakophilin 2 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human PKP2 at the amino acid range 632-681
Function Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins. Required to maintain gingival epithelial barrier function. Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes. Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls. Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments. Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling. May play a role in junctional plaques. Involved in the inhibition of viral infection by influenza A viruses (IAV). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins.
Protein Name Plakophilin-2
Database Links Reactome: R-HSA-6805567
Reactome: R-HSA-6809371
Cellular Localisation Nucleus
Cell Junction
Desmosome
Cytoplasm
Colocalizes With Ctnna3 And Scn5a/Nav1
5 At Intercalated Disks In The Heart
Alternative Antibody Names Anti-Plakophilin-2 antibody
Anti-PKP2 antibody

Information sourced from Uniprot.org

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