Anti-PKD1L1 antibody (STJ13101575)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from mouse PKD1L1 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-PKD1L1 for use in IHC and WB in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:1000 to 1:2000 is recommended. The optimal dilution should be determined by the end user. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Pkd1l1Uniprot ID=PK1L1_MOUSE" |
| Immunogen | A synthetic peptide from mouse PKD1L1 conjugated to blue carrier protein was used as the antigen. |
| Specificity | Specific for PK1L1. |
Additional Info
| Function | Component of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, without affecting cytoplasmic calcium concentration, and regulates sonic hedgehog/SHH signaling and GLI2 transcription. The PKD1L1:PKD2L1 channel complex is mechanosensitive only at high pressures and is highly temperature sensitive. Also involved in left/right axis specification downstream of nodal flow by forming a complex with PKD2 in cilia to facilitate flow detection in left/right patterning. May function as a G-protein-coupled receptor. |
| Protein Name | Polycystin-1-Like Protein 1Polycystin-1l1Pc1-Like 1 ProteinPolycystic Kidney Disease Protein 1-Like 1Protein Rikishi |
| Cellular Localisation | Cell ProjectionCilium MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Polycystin-1-Like Protein 1 antibodyAnti-Polycystin-1l1 antibodyAnti-Pc1-Like 1 Protein antibodyAnti-Polycystic Kidney Disease Protein 1-Like 1 antibodyAnti-Protein Rikishi antibodyAnti-Pkd1l1 antibodyAnti-Rks antibody |
Information sourced from Uniprot.org