| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Polycystin-1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PKD1 |
| Gene ID: |
5310 |
| Uniprot ID: |
PKD1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of Polycystin 1 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human Polycystin 1 |
| Function | Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Both PKD1 and PKD2 are required for channel activity. Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. |
| Protein Name | Polycystin-1Pc1Autosomal Dominant Polycystic Kidney Disease 1 Protein |
| Database Links | Reactome: R-HSA-5620916 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionCiliumEndoplasmic ReticulumGolgi ApparatusPkd1 Localization To The Plasma And Ciliary Membranes Requires Pkd2Is Independent Of Pkd2 Channel ActivityAnd Involves Stimulation Of Pkd1 Autoproteolytic Cleavage At The Gps DomainPkd1:Pkd2 Interaction Is Required To Reach The Golgi Apparatus From Endoplasmic Reticulum And Then Traffic To The CiliaCiliary Localization Of Pkd1 Requires Bbs1 And Arl6/Bbs3Cell Surface Localization Requires Ganab |
| Alternative Antibody Names | Anti-Polycystin-1 antibodyAnti-Pc1 antibodyAnti-Autosomal Dominant Polycystic Kidney Disease 1 Protein antibodyAnti-PKD1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
