Anti-PKA RI alpha antibody [R06-8A5] (STJA0034761)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human Protein Kinase A regulatory subunit I alpha
General Information
| Short Description | Rabbit monoclonal anti-PKA RI alpha for use in WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R06-8A5 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PRKAR1A |
| Gene ID | 5573 |
| Uniprot ID | KAP0_HUMAN |
| Immunogen | A synthetic peptide of human Protein Kinase A regulatory subunit I alpha |
Additional Info
| Tissue Specificity | Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. |
| Post Translational Modifications | The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity. |
| Function | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. |
| Protein Name | Camp-Dependent Protein Kinase Type I-Alpha Regulatory SubunitTissue-Specific Extinguisher 1Tse1 |
| Database Links | Reactome: R-HSA-163615Reactome: R-HSA-164378Reactome: R-HSA-180024Reactome: R-HSA-381676Reactome: R-HSA-432040Reactome: R-HSA-442720Reactome: R-HSA-5610787Reactome: R-HSA-9634597Reactome: R-HSA-9660821Reactome: R-HSA-9664323Reactome: R-HSA-9700645Reactome: R-HSA-9725370Reactome: R-HSA-983231Reactome: R-HSA-9856530 |
| Cellular Localisation | Cell Membrane |
| Alternative Antibody Names | Anti-Camp-Dependent Protein Kinase Type I-Alpha Regulatory Subunit antibodyAnti-Tissue-Specific Extinguisher 1 antibodyAnti-Tse1 antibodyAnti-PRKAR1A antibodyAnti-PKR1 antibodyAnti-PRKAR1 antibodyAnti-TSE1 antibody |
Information sourced from Uniprot.org