Anti-PJVK antibody (290-352) [S5209RM] (STJ11105209)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Pejvakin (290-352) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5209RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PJVK |
| Gene ID | 494513 |
| Uniprot ID | PJVK_HUMAN |
| Immunogen Region | 290-352 |
| Immunogen Sequence | KEGTHIRVNLLNHNIPKGPC ILCGMGNFKRETVYGCFQCS VDGQKYVRLHAVPCFDIWHK RMK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 290-352 of human PJVK ( NP_001036167.1 ). |
Additional Info
| Function | Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation. |
| Protein Name | PejvakinAutosomal Recessive Deafness Type 59 Protein |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Peroxisome MembraneCell ProjectionCiliumAssociates With The Peroxisomal MembraneIt Is Unclear Whether It Is Embedded Or Just Associated With The Peroxisomal MembraneLocalizes To Ciliary Rootlet |
| Alternative Antibody Names | Anti-Pejvakin antibodyAnti-Autosomal Recessive Deafness Type 59 Protein antibodyAnti-PJVK antibodyAnti-DFNB59 antibody |
Information sourced from Uniprot.org