Anti-PITX2 antibody (1-324) (STJ118845)

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STJ118845
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PITX2
Gene ID: 5308
Uniprot ID: PITX2_HUMAN
Immunogen Region: 1-324
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-324 of human Pituitary homeobox 2 (PITX2) (NP_000316.2).
Immunogen Sequence: MNCMKGPLHLEHRAAGTKLS AVSSSSCHHPQPLAMASVLA PGQPRSLDSSKHRLEVHTIS DTSSPEAAEKDKSQQGKNED VGAEDPSKKKRQRRQRTHFT SQQLQELEATFQRNRYPDMS TREEIAVWTNLTEARVRVWF KNRRAKWRKRERNQQAELCK NGFGPQFNGLMQPYDDMYPG YSYNNWAAKGLTSASLSTKS FPFFNSMNVNPLSSQSMFSP PNSISSMSMSSSMVPSAVT
Post Translational Modifications Phosphorylated at Thr-90 by AKT2, but not AKT1. Phosphorylation impairs its association with a CCND1 mRNA-stabilizing complex, thus shortening the half-life of CCND1.
Function May play a role in myoblast differentiation. When unphosphorylated, associates with an ELAVL1-containing complex, which stabilizes cyclin mRNA and ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation. Isoform PTX2C: Involved in the establishment of left-right asymmetry in the developing embryo.
Protein Name Pituitary Homeobox 2
All1-Responsive Protein Arp1
Homeobox Protein Pitx2
Paired-Like Homeodomain Transcription Factor 2
Rieg Bicoid-Related Homeobox Transcription Factor
Solurshin
Database Links Reactome: R-HSA-8866906
Cellular Localisation Nucleus
Cytoplasm
Alternative Antibody Names Anti-Pituitary Homeobox 2 antibody
Anti-All1-Responsive Protein Arp1 antibody
Anti-Homeobox Protein Pitx2 antibody
Anti-Paired-Like Homeodomain Transcription Factor 2 antibody
Anti-Rieg Bicoid-Related Homeobox Transcription Factor antibody
Anti-Solurshin antibody
Anti-PITX2 antibody
Anti-ARP1 antibody
Anti-RGS antibody
Anti-RIEG antibody
Anti-RIEG1 antibody

Information sourced from Uniprot.org

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