| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PITX2 (1-324) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PITX2 |
| Gene ID: |
5308 |
| Uniprot ID: |
PITX2_HUMAN |
| Immunogen Region: |
1-324 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-324 of human Pituitary homeobox 2 (PITX2) (NP_000316.2). |
| Immunogen Sequence: |
MNCMKGPLHLEHRAAGTKLS AVSSSSCHHPQPLAMASVLA PGQPRSLDSSKHRLEVHTIS DTSSPEAAEKDKSQQGKNED VGAEDPSKKKRQRRQRTHFT SQQLQELEATFQRNRYPDMS TREEIAVWTNLTEARVRVWF KNRRAKWRKRERNQQAELCK NGFGPQFNGLMQPYDDMYPG YSYNNWAAKGLTSASLSTKS FPFFNSMNVNPLSSQSMFSP PNSISSMSMSSSMVPSAVT |
| Post Translational Modifications | Phosphorylation at Thr-90 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1. |
| Function | Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo. |
| Protein Name | Pituitary Homeobox 2All1-Responsive Protein Arp1Homeobox Protein Pitx2Paired-Like Homeodomain Transcription Factor 2Rieg Bicoid-Related Homeobox Transcription FactorSolurshin |
| Database Links | Reactome: R-HSA-8866906 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pituitary Homeobox 2 antibodyAnti-All1-Responsive Protein Arp1 antibodyAnti-Homeobox Protein Pitx2 antibodyAnti-Paired-Like Homeodomain Transcription Factor 2 antibodyAnti-Rieg Bicoid-Related Homeobox Transcription Factor antibodyAnti-Solurshin antibodyAnti-PITX2 antibodyAnti-ARP1 antibodyAnti-RGS antibodyAnti-RIEG antibodyAnti-RIEG1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
