Anti-PITRM1 antibody (STJA0007631)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PITRM1
General Information
| Short Description | Rabbit polyclonal anti-Presequence protease, mitochondrial for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PITRM1 |
| Gene ID | 10531 |
| Uniprot ID | PREP_HUMAN |
| Immunogen | Synthesized peptide derived from human PITRM1 |
| Specificity | This antibody detects endogenous levels of PITRM1 at Human, Mouse |
Additional Info
| Post Translational Modifications | A disulfide bond locks the enzyme in the closed conformation preventing substrate entry into the catalytic chamber. |
| Function | Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently. It is also able to degrade amyloid-beta protein 42. |
| Protein Name | Presequence Protease - MitochondrialHprepPitrilysin Metalloproteinase 1Metalloprotease 1Hmp1 |
| Database Links | Reactome: R-HSA-1268020 |
| Cellular Localisation | MitochondrionMitochondrion Matrix |
| Alternative Antibody Names | Anti-Presequence Protease - Mitochondrial antibodyAnti-Hprep antibodyAnti-Pitrilysin Metalloproteinase 1 antibodyAnti-Metalloprotease 1 antibodyAnti-Hmp1 antibodyAnti-PITRM1 antibodyAnti-KIAA1104 antibodyAnti-MP1 antibodyAnti-PREP antibody |
Information sourced from Uniprot.org