Anti-PITPNM1 antibody (110-190) (STJ115030)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PITPNM1 (110-190) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PITPNM1 |
| Gene ID | 9600 |
| Uniprot ID | PITM1_HUMAN |
| Immunogen Region | 110-190 |
| Immunogen Sequence | EIETYYLPDGGQQPNVFNLS GAERRQRILDTIDIVRDAVA PGEYKAEEDPRLYHSVKTGR GPLSDDWARTAAQTGPLMCA Y |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 110-190 of human PITPNM1 (NP_004901.2). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylated on multiple sites by CDK1 at the onset of mitosis. Phosphorylation facilitates dissociation from the Golgi complex and is required for interaction with PLK1. Phosphorylated on threonine residues upon treatment with oleic acid. Phosphorylated on tyrosine residues by PTK2B. |
| Function | Catalyzes the transfer of phosphatidylinositol (PI) between membranes. Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC. Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions. |
| Protein Name | Membrane-Associated Phosphatidylinositol Transfer Protein 1Drosophila Retinal Degeneration B HomologPhosphatidylinositol Transfer Protein - Membrane-Associated 1Pitpnm 1Pyk2 N-Terminal Domain-Interacting Receptor 2Nir-2 |
| Database Links | Reactome: R-HSA-1483226 |
| Cellular Localisation | CytoplasmGolgi ApparatusGolgi Stack MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneLipid DropletCleavage FurrowMidbodyPeripheral Membrane Protein Associated With Golgi Stacks In Interphase CellsA Minor Proportion Is Associated With The Endoplasmic ReticulumAssociated With Lipid DropletsDissociates From The Golgi Early On In Mitosis And Localizes To The Cleavage Furrow And Midbody During Cytokinesis |
| Alternative Antibody Names | Anti-Membrane-Associated Phosphatidylinositol Transfer Protein 1 antibodyAnti-Drosophila Retinal Degeneration B Homolog antibodyAnti-Phosphatidylinositol Transfer Protein - Membrane-Associated 1 antibodyAnti-Pitpnm 1 antibodyAnti-Pyk2 N-Terminal Domain-Interacting Receptor 2 antibodyAnti-Nir-2 antibodyAnti-PITPNM1 antibodyAnti-DRES9 antibodyAnti-NIR2 antibodyAnti-PITPNM antibody |
Information sourced from Uniprot.org