Anti-Pirin antibody (N-Term) (STJ70575)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Pirin (N-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 33kDa band observed in Human Heart lysate (calculated MW of 32.1kDa according to NP_003653.1). Recommended concentration: 0.3-1.0 µg/ml. Primary incubation was 1 hour.IHC: |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PIR |
| Gene ID | 8544 |
| Uniprot ID | PIR_HUMAN |
| Accession Number | NP_003653.1 |
| Immunogen Region | N-Term |
| Immunogen Sequence | GSSKKVTLSVLSREC |
| Specificity | Variants (NP_003653.1; NP_001018119.1) encode the same protein |
Additional Info
| Function | Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). |
| Protein Name | PirinProbable Quercetin 2 -3-Dioxygenase PirProbable Quercetinase |
| Database Links | Reactome: R-HSA-8935690 |
| Cellular Localisation | NucleusCytoplasmPredominantly Localized In Dot-Like Subnuclear StructuresCytoplasmic Localization Of Pir Seems To Positively Correlate With Melanoma Progression |
| Alternative Antibody Names | Anti-Pirin antibodyAnti-Probable Quercetin 2 -3-Dioxygenase Pir antibodyAnti-Probable Quercetinase antibodyAnti-PIR antibody |
Information sourced from Uniprot.org