Anti-Pirh2 antibody (STJA0037522)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein
General Information
| Short Description | Rabbit monoclonal anti-Pirh2 for use in WB, IHC-F, IHC-P, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-F/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | WB-1:500-1:1000IHC-1:50-1:100IF-1:50-1:200 |
| Formulation | Liquid in 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | RCHY1 |
| Gene ID | 25898 |
| Uniprot ID | ZN363_HUMAN |
| Immunogen | Recombinant protein |
Additional Info
| Post Translational Modifications | Subject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B. Mediates ubiquitination and degradation of p53/TP53.preferentially acts on tetrameric p53/TP53. Catalyzes monoubiquitinates the translesion DNA polymerase POLH. Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation. Isoform 4: Has no E3 ubiquitin-protein ligase activity. |
| Protein Name | Ring Finger And Chy Zinc Finger Domain-Containing Protein 1Androgen Receptor N-Terminal-Interacting ProteinCh-Rich-Interacting Match With Plag1E3 Ubiquitin-Protein Ligase Pirh2Ring Finger Protein 199Ring-Type E3 Ubiquitin Transferase Rchy1Zinc Finger Protein 363P53-Induced Ring-H2 ProteinHpirh2 |
| Database Links | Reactome: R-HSA-110320Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasm |
| Alternative Antibody Names | Anti-Ring Finger And Chy Zinc Finger Domain-Containing Protein 1 antibodyAnti-Androgen Receptor N-Terminal-Interacting Protein antibodyAnti-Ch-Rich-Interacting Match With Plag1 antibodyAnti-E3 Ubiquitin-Protein Ligase Pirh2 antibodyAnti-Ring Finger Protein 199 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rchy1 antibodyAnti-Zinc Finger Protein 363 antibodyAnti-P53-Induced Ring-H2 Protein antibodyAnti-Hpirh2 antibodyAnti-RCHY1 antibodyAnti-ARNIP antibodyAnti-CHIMP antibodyAnti-PIRH2 antibodyAnti-RNF199 antibodyAnti-ZNF363 antibody |
Information sourced from Uniprot.org