Anti-PIR antibody (STJA0008161)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PIR
General Information
| Short Description | Rabbit polyclonal anti-Pirin for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PIR |
| Gene ID | 8544 |
| Uniprot ID | PIR_HUMAN |
| Immunogen | Synthesized peptide derived from human PIR |
| Specificity | This antibody detects endogenous levels of PIR at Human, Mouse, Rat |
Additional Info
| Function | Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). |
| Protein Name | PirinProbable Quercetin 2 -3-Dioxygenase PirProbable Quercetinase |
| Database Links | Reactome: R-HSA-8935690 |
| Cellular Localisation | NucleusCytoplasmPredominantly Localized In Dot-Like Subnuclear StructuresCytoplasmic Localization Of Pir Seems To Positively Correlate With Melanoma Progression |
| Alternative Antibody Names | Anti-Pirin antibodyAnti-Probable Quercetin 2 -3-Dioxygenase Pir antibodyAnti-Probable Quercetinase antibodyAnti-PIR antibody |
Information sourced from Uniprot.org