Anti-PIP5K1B antibody (STJA0007201)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PIP5K1B
General Information
| Short Description | Rabbit polyclonal anti-Phosphatidylinositol 4-phosphate 5-kinase type-1 betaP-5-kinase 1 beta for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PIP5K1B |
| Gene ID | 8395 |
| Uniprot ID | PI51B_HUMAN |
| Immunogen | Synthesized peptide derived from human PIP5K1B |
| Specificity | This antibody detects endogenous levels of PIP5K1B at Human, Mouse, Rat |
Additional Info
| Function | Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility. PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion. |
| Protein Name | Phosphatidylinositol 4-Phosphate 5-Kinase Type-1 BetaPip5k1-BetaPtdins(4p-5-Kinase 1 BetaPhosphatidylinositol 4-Phosphate 5-Kinase Type I BetaPip5kibetaProtein Stm-7Type I Phosphatidylinositol 4-Phosphate 5-Kinase Beta |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-201688Reactome: R-HSA-6811558 |
| Cellular Localisation | CytoplasmCytosolCell MembraneEndomembrane SystemAssociated With Membranes |
| Alternative Antibody Names | Anti-Phosphatidylinositol 4-Phosphate 5-Kinase Type-1 Beta antibodyAnti-Pip5k1-Beta antibodyAnti-Ptdins(4p-5-Kinase 1 Beta antibodyAnti-Phosphatidylinositol 4-Phosphate 5-Kinase Type I Beta antibodyAnti-Pip5kibeta antibodyAnti-Protein Stm-7 antibodyAnti-Type I Phosphatidylinositol 4-Phosphate 5-Kinase Beta antibodyAnti-PIP5K1B antibodyAnti-STM7 antibody |
Information sourced from Uniprot.org