Anti-PIP4K2A antibody (STJA0008345)

SKU:
STJA0008345

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phosphatidylinositol 5-phosphate 4-kinase type-2 alphaP 4-kinase type II alphaP-5-kinase B isoformP-5-kinase C isoformP-4-kinase isoform 2-alpha is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PIP4K2A
Gene ID: 5305
Uniprot ID: PI42A_HUMAN
Specificity: This antibody detects endogenous levels of PIP4K2A at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human PIP4K2A
Post Translational Modifications Phosphorylated in tyrosines. Phosphorylation is induced by light and increases kinase activity.
Function Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities. May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level. In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress. Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size. Negatively regulates insulin signaling through a catalytic-independent mechanism. PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3.
Protein Name Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Alpha
1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Alpha
Diphosphoinositide Kinase 2-Alpha
Pip5kiii
Phosphatidylinositol 5-Phosphate 4-Kinase
Pi5p4kalpha
Phosphatidylinositol 5-Phosphate 4-Kinase Type Ii Alpha
Pi(5p 4-Kinase Type Ii Alpha
Pip4kii-Alpha
Ptdins(4p-5-Kinase B Isoform
Ptdins(4p-5-Kinase C Isoform
Ptdins(5p-4-Kinase Isoform 2-Alpha
Database Links Reactome: R-HSA-1660499
Reactome: R-HSA-6811555
Reactome: R-HSA-6811558
Reactome: R-HSA-8847453
Cellular Localisation Cell Membrane
Nucleus
Lysosome
Cytoplasm
Photoreceptor Inner Segment
Cell Projection
Cilium
Photoreceptor Outer Segment
May Translocate From The Cytosol To The Cell Membrane Upon Activation Of Tyrosine Phosphorylation
May Translocate From The Inner To The Outer Segments Of The Rod Photoreceptor Cells In Response To Light
Localization To The Nucleus Is Modulated By The Interaction With Pip4k2b
Alternative Antibody Names Anti-Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Alpha antibody
Anti-1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Alpha antibody
Anti-Diphosphoinositide Kinase 2-Alpha antibody
Anti-Pip5kiii antibody
Anti-Phosphatidylinositol 5-Phosphate 4-Kinase antibody
Anti-Pi5p4kalpha antibody
Anti-Phosphatidylinositol 5-Phosphate 4-Kinase Type Ii Alpha antibody
Anti-Pi(5p 4-Kinase Type Ii Alpha antibody
Anti-Pip4kii-Alpha antibody
Anti-Ptdins(4p-5-Kinase B Isoform antibody
Anti-Ptdins(4p-5-Kinase C Isoform antibody
Anti-Ptdins(5p-4-Kinase Isoform 2-Alpha antibody
Anti-PIP4K2A antibody
Anti-PI5P4KA antibody
Anti-PIP5K2 antibody
Anti-PIP5K2A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance