| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PIN4 |
| Gene ID: |
5303 |
| Uniprot ID: |
PIN4_HUMAN |
| Specificity: |
This antibody detects endogenous levels of PIN4 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human PIN4 |
| Post Translational Modifications | Phosphorylated. Isoform 1 phosphorylation occurs both in the nucleus and the cytoplasm. Isoform 1 phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated isoform 1 associates with the pre-rRNP complexes in the nucleus. Isoform 2 is sumoylated with SUMO2 and SUMO3. |
| Function | Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. Isoform 2 binds to double-stranded DNA. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Nima-Interacting 4Parvulin-14Par14Hpar14Parvulin-17Par17Hpar17Peptidyl-Prolyl Cis-Trans Isomerase Pin4Ppiase Pin4Peptidyl-Prolyl Cis/Trans Isomerase EpvhHepvhRotamase Pin4 |
| Cellular Localisation | Isoform 1: NucleusNucleolusCytoplasmCytoskeletonSpindleColocalizes In The Nucleolus During Interphase And On The Spindle Apparatus During Mitosis With Npm1Isoform 2: MitochondrionMitochondrion MatrixImported In A Time- And Membrane Potential-Dependent Manner To The Mitochondrial MatrixBut Without Concomitant Processing Of The ProteinDirected To Mitochondria By A Novel N-Terminal Domain That Functions As Non-Cleavable Mitochondrial Targeting Peptide |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase Nima-Interacting 4 antibodyAnti-Parvulin-14 antibodyAnti-Par14 antibodyAnti-Hpar14 antibodyAnti-Parvulin-17 antibodyAnti-Par17 antibodyAnti-Hpar17 antibodyAnti-Peptidyl-Prolyl Cis-Trans Isomerase Pin4 antibodyAnti-Ppiase Pin4 antibodyAnti-Peptidyl-Prolyl Cis/Trans Isomerase Epvh antibodyAnti-Hepvh antibodyAnti-Rotamase Pin4 antibodyAnti-PIN4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
