| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phosphoinositide 3-kinase regulatory subunit 4 (170-220) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PIK3R4 |
| Gene ID: |
30849 |
| Uniprot ID: |
PI3R4_HUMAN |
| Immunogen Region: |
170-220 |
| Specificity: |
This antibody detects endogenous levels of human PI3R4 |
| Immunogen: |
Synthesized peptide derived from human PI3R4 AA range: 170-220 |
| Post Translational Modifications | Myristoylated. Probably autophosphorylated. |
| Function | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate.different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2. |
| Protein Name | Phosphoinositide 3-Kinase Regulatory Subunit 4Pi3-Kinase Regulatory Subunit 4Pi3-Kinase P150 SubunitPhosphoinositide 3-Kinase Adaptor Protein |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-1632852Reactome: R-HSA-1660514Reactome: R-HSA-1660516Reactome: R-HSA-1660517Reactome: R-HSA-168138Reactome: R-HSA-5668599Reactome: R-HSA-9679504Reactome: R-HSA-9694676Reactome: R-HSA-9705671Reactome: R-HSA-983170 |
| Cellular Localisation | Late EndosomeCytoplasmic VesicleAutophagosomeMembraneLipid-AnchorAs Component Of The Pi3k Complex I Localized To Pre-Autophagosome StructuresAs Component Of The Pi3k Complex Ii Localized Predominantly To EndosomesLocalizes Also To Discrete Punctae Along The Ciliary Axoneme |
| Alternative Antibody Names | Anti-Phosphoinositide 3-Kinase Regulatory Subunit 4 antibodyAnti-Pi3-Kinase Regulatory Subunit 4 antibodyAnti-Pi3-Kinase P150 Subunit antibodyAnti-Phosphoinositide 3-Kinase Adaptor Protein antibodyAnti-PIK3R4 antibodyAnti-VPS15 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
