Anti-PIBF1 antibody (STJA0007508)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PIBF1
General Information
| Short Description | Rabbit polyclonal anti-Progesterone-induced-blocking factor 1 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PIBF1 |
| Gene ID | 10464 |
| Uniprot ID | PIBF1_HUMAN |
| Immunogen | Synthesized peptide derived from human PIBF1 |
| Specificity | This antibody detects endogenous levels of PIBF1 at Human |
Additional Info
| Function | Plays a role in ciliogenesis. Isoform 1: Pericentriolar protein required to maintain mitotic spindle pole integrity. Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation. Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2. Isoform 4: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual natural killer cells (NK) activity exerts an anti-abortive effect. Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein. |
| Protein Name | Progesterone-Induced-Blocking Factor 1PibfCentrosomal Protein Of 90 KdaCep90 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSecretedIn Progesterone-Treated Astrocytoma Cells A 57 Kda Protein And Isoform 1 (90 Kda) Have Been DescribedBoth Being Located In The Intracellular Medium And SecretedRespective Predominant Forms Are Isoform 1 In The Intracellular And The 57 Kda Protein In The Extracellular MediumIsoform 1: NucleusCentriolar SatelliteLocalizes To Centriolar Satellites Throughout The Cell CycleIsoform 4: SecretedSecreted By Progesterone-Treated Lymphocytes |
| Alternative Antibody Names | Anti-Progesterone-Induced-Blocking Factor 1 antibodyAnti-Pibf antibodyAnti-Centrosomal Protein Of 90 Kda antibodyAnti-Cep90 antibodyAnti-PIBF1 antibodyAnti-C13orf24 antibodyAnti-PIBF antibody |
Information sourced from Uniprot.org