| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PIAS3 (399-628) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PIAS3 |
| Gene ID: |
10401 |
| Uniprot ID: |
PIAS3_HUMAN |
| Immunogen Region: |
399-628 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 399-628 of human PIAS3 (NP_006090.2). |
| Immunogen Sequence: |
FMEDGSWCPMKPKKEASEVC PPPGYGLDGLQYSPVQGGDP SENKKKVEVIDLTIESSSDE EDLPPTKKHCSVTSAAIPAL PGSKGVLTSGHQPSSVLRSP AMGTLGGDFLSSLPLHEYPP AFPLGADIQGLDLFSFLQTE SQHYGPSVITSLDEQDALGH FFQYRGTPSHFLGPLAPTLG SSHCSATPAPPPGRVSSIVA PGGALREGHGGPLPSGPSLT GCRSDIISLD |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Sumoylated. |
| Function | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which promotes its interaction with SIRT1. Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus. |
| Protein Name | E3 Sumo-Protein Ligase Pias3E3 Sumo-Protein Transferase Pias3Protein Inhibitor Of Activated Stat Protein 3 |
| Database Links | Reactome: R-HSA-3232118Reactome: R-HSA-3899300Reactome: R-HSA-4090294Reactome: R-HSA-4615885Reactome: R-HSA-4755510Reactome: R-HSA-5696395 |
| Cellular Localisation | CytoplasmNucleusNucleus SpeckleColocalizes With Mitf In The NucleusColocalizes With Gfi1 In Nuclear DotsColocalizes With Sumo1 In Nuclear Granules |
| Alternative Antibody Names | Anti-E3 Sumo-Protein Ligase Pias3 antibodyAnti-E3 Sumo-Protein Transferase Pias3 antibodyAnti-Protein Inhibitor Of Activated Stat Protein 3 antibodyAnti-PIAS3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
