Anti-PI3R6 antibody (590-640) (STJ506050)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 590-640 on human PhosphoInositide 3-kinase regulatory subunit 6.
General Information
| Short Description | Rabbit polyclonal antibody anti-PI3R6 (590-640) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5-1.5 ยตg/ยตl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500ELISA: 1:50, 000IP: 1:200 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | PIK3R6 |
| Gene ID | 146850 |
| Uniprot ID | PI3R6_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 590-640 on human PhosphoInositide 3-kinase regulatory subunit 6. |
| Immunogen Region | 590-640 |
Additional Info
| Function | Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis.signaling seems to involve RRAS. |
| Protein Name | Phosphoinositide 3-Kinase Regulatory Subunit 6Phosphoinositide 3-Kinase Gamma Adapter Protein Of 87 KdaP84 Pi3k Adapter ProteinP84 PikapP87 Pi3k Adapter ProteinP87pikap |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-1660499Reactome: R-HSA-392451 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinTranslocated To The Plasma Membrane In A Ras-Dependent Manner |
| Alternative Antibody Names | Anti-Phosphoinositide 3-Kinase Regulatory Subunit 6 antibodyAnti-Phosphoinositide 3-Kinase Gamma Adapter Protein Of 87 Kda antibodyAnti-P84 Pi3k Adapter Protein antibodyAnti-P84 Pikap antibodyAnti-P87 Pi3k Adapter Protein antibodyAnti-P87pikap antibodyAnti-PIK3R6 antibodyAnti-C17orf38 antibody |
Information sourced from Uniprot.org