| Function | Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis.signaling seems to involve RRAS. |
| Protein Name | Phosphoinositide 3-Kinase Regulatory Subunit 6Phosphoinositide 3-Kinase Gamma Adapter Protein Of 87 KdaP84 Pi3k Adapter ProteinP84 PikapP87 Pi3k Adapter ProteinP87pikap |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-1660499Reactome: R-HSA-392451 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinTranslocated To The Plasma Membrane In A Ras-Dependent Manner |
| Alternative Antibody Names | Anti-Phosphoinositide 3-Kinase Regulatory Subunit 6 antibodyAnti-Phosphoinositide 3-Kinase Gamma Adapter Protein Of 87 Kda antibodyAnti-P84 Pi3k Adapter Protein antibodyAnti-P84 Pikap antibodyAnti-P87 Pi3k Adapter Protein antibodyAnti-P87pikap antibodyAnti-PIK3R6 antibodyAnti-C17orf38 antibody |
Information sourced from Uniprot.org
